Saudi Journal for Health Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 10  |  Issue : 1  |  Page : 7--13

The impact of chronic periodontitis on serum tumor necrosis factor-α and HbA1c levels in type 2 diabetic patients


Rehab Abdallah Abdalrahman1, Bakri Gobara Gismalla2 
1 Periodontic Department, Khartoum Teaching Dental Hospital, Khartoum, Sudan
2 Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan

Correspondence Address:
Rehab Abdallah Abdalrahman
Khartoum Teaching Dental Hospital, Khartoum
Sudan

Background: Diabetic patients are subject to chronic periodontitis which could adversely affect glycemic control. Aim: This study determined the impact of chronic periodontitis in patients with diabetes mellitus type 2 (DM 2). Materials and Methods: We compared the levels of serum tumor necrosis factor-alpha (TNF-α) and HbA1c% between DM 2 patients with chronic periodontitis (study group) and DM 2 patients without chronic periodontitis (control group). Results: Statistically significant differences in fasting blood glucose (FBS), HbA1c, and gingival index (GI) were observed between the study and control group. No differences were found in TNF-α between the patients of both the groups. However, higher levels of TNF-α and FBS were shown in diabetic patients with mild periodontitis group than in those with moderate or severe periodontitis. Conclusion: Chronic periodontitis could affect HbA1c levels in DM 2 patients. In addition, HbA1c was positively correlated with FBS and GI, while negatively correlated with TNF-α, which exhibited a higher level in mild periodontitis compared with severe and moderate periodontitis.


How to cite this article:
Abdalrahman RA, Gismalla BG. The impact of chronic periodontitis on serum tumor necrosis factor-α and HbA1c levels in type 2 diabetic patients.Saudi J Health Sci 2021;10:7-13


How to cite this URL:
Abdalrahman RA, Gismalla BG. The impact of chronic periodontitis on serum tumor necrosis factor-α and HbA1c levels in type 2 diabetic patients. Saudi J Health Sci [serial online] 2021 [cited 2021 Jun 12 ];10:7-13
Available from: https://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=1;spage=7;epage=13;aulast=Abdalrahman;type=0