Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
    Users Online: 35
Home Print this page Email this page Small font size Default font size Increase font size

 Table of Contents  
Year : 2016  |  Volume : 5  |  Issue : 2  |  Page : 93-96

Successful laparoscopic-assisted Davydov operation for the treatment of complete congenital vaginal agenesis at a public health facility in Ilorin, Nigeria

1 Department of Obstetrics and Gynaecology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
2 Department of Surgery, College of Health Sciences, University of Ilorin, Ilorin, Nigeria

Date of Web Publication25-Oct-2016

Correspondence Address:
Omokanye Lukman Omotayo
Department of Obstetrics and Gynaecology, College of Health Sciences, University of Ilorin, Ilorin
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0521.193012

Rights and Permissions

Mayer-Rokitansky-Kuster-Hauser is a rare congenital anomaly of the female genital tract that may remain undiagnosed until adolescence, early adulthood, or during marital life. It is caused by embryonic growth failure resulting in agenesis or underdevelopment of the vagina or uterus or both. Satisfactory vagina creation remains a challenge, however there is no standard treatment for creating a vagina though a variety of surgical options have been tried. We present a case of laparoscopic-assisted Davydov operation in a 25-year-old female with complete congenital vagina agenesis.

Keywords: Davydov operation, Ilorin, Nigeria, vaginal agenesis

How to cite this article:
Omotayo OL, Ogunkeyede A O, Adewole MA, Olatinwo AO. Successful laparoscopic-assisted Davydov operation for the treatment of complete congenital vaginal agenesis at a public health facility in Ilorin, Nigeria. Saudi J Health Sci 2016;5:93-6

How to cite this URL:
Omotayo OL, Ogunkeyede A O, Adewole MA, Olatinwo AO. Successful laparoscopic-assisted Davydov operation for the treatment of complete congenital vaginal agenesis at a public health facility in Ilorin, Nigeria. Saudi J Health Sci [serial online] 2016 [cited 2021 Jan 18];5:93-6. Available from: https://www.saudijhealthsci.org/text.asp?2016/5/2/93/193012

  Introduction Top

Mullerian agenesis is also referred as mullerian aplasia, Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, or vagina agenesis. It occurs in 1 in 4,000-5,000 female live births, [1] the majority of cases appears to be sporadic, however familial cases have been described. Most gynecologists will only encounter mullerian agenesis once or twice during their carrier. [2] Patient with MRKH syndrome may present with any of the following symptoms: Primary amenorrhea with a normal female phenotype and 46, XX karyotype; MRKH accounts for 15% of primary amenorrhea, [3] inability to have intercourse, infertility, renal malformation, and vertebral anomalies.

MRKH is subdivided into two types. Type I consists of an isolated absence of the proximal two-thirds of the vagina and the uterus, whereas Type II is associated with other anomalies which include vertebral, cardiac, urologic, and otologic abnormalities. [4] Both present with normal female sexual development.

The diagnosis of vaginal agenesis is emotionally traumatic for these young women. The physicians' approach is very important for their psychological well-being and future medical management. [5] At present, there is no consensus regarding the best management option. As stated by the American College of Obstetrician and Gynaecology (ACOG Committee Opinion, 2002), nonsurgical treatment is the first choice, [6] however anatomic and functional success rate of dilator therapy is questionable. In patients who refuse or fail to achieve a functional vagina with passive dilatation, a surgical approach may be required. Successful results with various vaginoplasty techniques have been described. We present a case of laparoscopic-assisted Davydov operation in a 25-year-old woman with complete congenital vagina agenesis.

  Case report Top

A 25-year-old woman presented at the assisted reproductive technology (ART) unit of the Department of Obstetrics and Gynaecology, University of Ilorin, Teaching Hospital, on account of primary amenorrhea. She had started developing secondary sexual characteristics at about 14 years of age; the sequence of development could not be remembered. She was not sexually active.

Physical examination revealed a young woman, 1.46 m tall, weighed 42 kg, and her body mass index was 19.7 kg/m 2 . Her thumbs were hypoplastic bilaterally and she had a short neck. Her breasts were well developed at tanner stage V with normal axillary and pubic hair. The gynecological examination revealed grossly normal vulva, however the vagina was blind-ending with only the urethral opening being patent. The two-dimensional transvaginal ultrasonography done revealed absent uterus and normal ovaries with evidence of follicular activities. She subsequently had diagnostic laparoscopy done and the uterus was not visualized; however, grossly, normal  Fallopian tube More Detailss and ovaries were seen bilaterally. The patient was discharged home on the same day after diagnostic laparoscopy and counseled on the operative findings and the need for vaginoplasty and ART with surrogate mother.

The patient represented the clinic 2 months later seeking for vaginoplasty because of her readiness to get marry. She was co-managed with a plastic surgeon, and the decision to offer her laparoscopically assisted Davydov vaginoplasty was jointly arrived at.

Laparoscopic creation of a new vagina was based on Davydov method. Blunt dissections were made abdominally over a vagina mold placed at the rectoversical space. A transverse incision was made over the mold with the aid of a monopolar laparoscopic spatula to create a neovagina, and the anterior and posterior peritoneal flaps created were separately held with a stay suture (Vicryl 2), then pulled toward the perineum and sutured to the vaginal edges by the plastic surgeon with Vicryl 4/0. Vaginal vault was constructed using purse-string suture involving a bite on the round ligaments, serosa of the sigmoid colon, and uterovesical peritoneum, which were approximated with the aid of tumble square knot [Figure 1],[Figure 2],[Figure 3],[Figure 4],[Figure 5],[Figure 6] and [Figure 7].
Figure 1: Absent vagina

Click here to view
Figure 2: Laparoscopic creation of neovagina

Click here to view
Figure 3: Cutting of stay sutures

Click here to view
Figure 4: Pull-through of peritoneal stay sutures held at the perineum by a plastic surgeon

Click here to view
Figure 5: Suturing of the peritoneum to the neovagina edges

Click here to view
Figure 6: Vaginal vault creation using purse-string suture with tumble square knotting

Click here to view
Figure 7: The neovagina vault

Click here to view

  Discussion Top

The MRKH syndrome should be suspected when a young female complaints of primary amenorrhea and the inability of sexual intercourse. The diagnosis is usually accessible using clinical information, laboratory results, and ultrasonographic findings. [1] If these findings are inconclusive, laparoscopy is indicated for objective confirmation of localization and photographic documentation of the internal genitalia, other neighboring structures, and possibly laparoscopically assisted vaginoplasty as one-off approach management in skill hands. [1],[7] In this report, the patient had both diagnostic and therapeutic laparoscopy for confirmatory diagnosis of MRKH and creation of neovagina. Thus, laparoscopy is a way of minimizing surgery-associated risks in the course of managing MRKH.

The surgical techniques are designed to create a canal of adequate size oriented in the correct axis by developing the space situated between the bladder and rectum. The newly created space may be covered by different materials: Skin graft, peritoneum, amnion, intestine; ileum, sigmoid colon, caecum, and artificial dermis. [5] Whatever the technique used, its success or failure depends largely on the cooperation of the patient and its associated complications, i.e., poor esthetic results in McIndoe skin graft, risk of peritonitis, intestinal obstruction, prolapse, excess mucous production, adenocarcinoma, and colitis of the neovagina in the intestinal graft. [8] The amnion graft can transmit hepatitis or human immunodeficiency virus, although the use of freeze-dried amnion prevents such transmission. [9]

The choice of laparoscopically assisted Davydov operation in this report was influenced by relative ease of its conduct in experienced hands with excellent results on long-term follow-up, the neovagina, with epithelium lining resembles that of a normal vagina, facilitates comfortable sexual intercourse, minimal short- and long-term care is required, fertility enhancing in assisted conception, and practically devoid of morbidity associated with other techniques. [9]

  Conclusion Top

Successful creation of a sexually functional neovagina should include the least possible diagnostic, operative, and postoperative discomfort to minimize and stabilize the vulnerable psychological situation of young patients with vagina agenesis. Hence, there is a need to prioritize this operation among others considering its numerous advantages, most especially fertility-enhancing ability for ease of ovum pick up for those seeking assisted conception.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Omokanye LO, Olatinwo AW, Durowade KA, Panti AA, Salaudeen AG, Adewara EO. Mayer-Rokitansky-Kuster-Hauser syndrome type I with karyotype XY variant: A case study. TJHS 2015;22:25-7.  Back to cited text no. 1
Committee on Adolescent Health Care. Committee opinion: No 562: müllerian agenesis: Diagnosis, management, and treatment. Obstet Gynecol 2013;121:1134-7.  Back to cited text no. 2
Folch M, Pigem I, Konje JC. Müllerian agenesis: Etiology, diagnosis, and management. Obstet Gynecol Surv 2000;55:644-9.  Back to cited text no. 3
Morcel K, Guerrier D, Watrin T, Pellerin I, Levêque J. The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: Clinical description and genetics. J Gynecol Obstet Biol Reprod (Paris) 2008;37:539-46.  Back to cited text no. 4
Giannesi A, Marchiole P, Benchaib M, Chevret-Measson M, Mathevet P, Dargent D. Sexuality after laparoscopic Davydov in patients affected by congenital complete vaginal agenesis associated with uterine agenesis or hypoplasia. Hum Reprod 2005;20:2954-7.  Back to cited text no. 5
ACOG Committee on Adolescent Health Care. ACOG Committee Opinion. Number 274, July 2002. Nonsurgical diagnosis and management of vaginal agenesis. Obstet Gynecol 2002;100:213-6.  Back to cited text no. 6
Mueller GC, Hussain HK, Smith YR, Quint EH, Carlos RC, Johnson TD, et al. Müllerian duct anomalies: Comparison of MRI diagnosis and clinical diagnosis. AJR Am J Roentgenol 2007;189:1294-302.  Back to cited text no. 7
Viola MI, van der Merwe JP, Siebert TI, Kruger TF. Neovagina creation-laparoscopic vecchietti-based approach with the new kit. S Afr J Obstet Gynaecol 2013;19:14-6.  Back to cited text no. 8
Mhatre P, Mhatre J, Sahu R. New laparoscopic peritoneal pull-through vaginoplasty technique. J Hum Reprod Sci 2014;7:181-6.  Back to cited text no. 9
[PUBMED]  Medknow Journal  


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Case report
Article Figures

 Article Access Statistics
    PDF Downloaded99    
    Comments [Add]    

Recommend this journal