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REVIEW ARTICLE
Year : 2014  |  Volume : 3  |  Issue : 2  |  Page : 71-74

A systemic review of antimicrobial resistance pattern of methicillin-resistant Staphylococcus aureus


1 Department of Medical Microbiology and Immunology, Institute of Bio-medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
2 Department of Gynecology and Obstetrics, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

Correspondence Address:
Tewelde Tesfaye Gebremariam
Department of Medical Microbiology and Immunology, Institute of Bio Medical Sciences, College of Health Sciences, Mekelle University, P.O.Box: 1168, Mekelle
Ethiopia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.134848

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Antimicrobial resistance of methicillin-resistant Staphylococcus aureus (MRSA) continues to be a problem for clinicians worldwide. It poses a serious therapeutic problem, leading to prolonged hospital stay and increased health-care costs. Current therapeutic options for MRSA are limited few expensive drugs. This study is a systematic review of published studies on MRSA and evaluates their antibiotic resistance pattern, and major finding as related to the objective of the study. Antimicrobial resistance of MRSA is based on CSLI guidelines-either disc diffusion or MIC methods. MRSA detection is either by classical methods for determining MICs (disc diffusion, Etest, or broth dilution), or screening techniques with solid culture medium containing oxacillin/cefoxitin and methods that detect the mecA gene or its protein product (PBP20 protein); S. aureus isolation should be based on standard bacteriological procedures: Tube/slide coagulase test or specific test like Pastorex or StaphID. A total of 33 studies were identified investigating the antimicrobial resistance of MRSA; of which 19 were included in the review. The majority of studies reported high levels of MRSA resistance against different antimicrobials. However, low levels of vancomycin resistance have been reported. Therefore, the knowledge of antimicrobial resistance of MRSA becomes necessary in the selection of appropriate empirical treatment of these infections. In addition, by employing a variety of prevention strategies, marked progress can be achieved in the control of drug-resistant pathogens, which can translate into more effective antimicrobial therapy.


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