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ORIGINAL ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 1  |  Page : 14-17

Nasal methicillin-resistant Staphylococcus aureus colonization in HIV-infected patients from eastern India


Department of Microbiology, R.G. Kar Medical College, Kolkata, India

Correspondence Address:
Simit Kumar
Department of Microbiology, R.G. Kar Medical College and Hospital, Kolkata
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.112625

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Background: Human immunodeficiency virus (HIV)-infected patients are now recognized as one of the higher risk groups for increased rates of both methicillin-resistant Staphylococcus aureus (MRSA) colonization and infections over the past decade. Staphylococcus aureus are known to colonize the anterior nares of HIV-infected patients with greater frequency than that of the general population, leading authors to postulate that this higher colonization burden might translate into a higher incidence of infections. Settings and Design: The study was a prospective study, including HIV-infected patients. Exclusion criteria: Patients having diabetes or any other immunodeficient conditions besides HIV. Materials and Methods: One hundred and forty two non-duplicate patients with HIV infection, attending the anti-retroviral therapy (ART) center at a tertiary care hospital were studied for nasal carriage of MRSA and associated factors affecting nasal colonization. Nasal swabs were used for isolation of S. aureus. MRSA were detected by using cefoxitin (30 μg) disc as per the Clinical Laboratory Standards Institute (CLSI) guidelines. Careful examination for dermatoses was carried out. Statistical Analysis: Descriptive statistics and testing of hypothesis were used for the analysis using SPSS 16 software. Results and Conclusions: Seventy two (50.70%) of the 142 patients were colonized with S. aureus in the anterior nares. Significant number of S. aureus carriers were in the 31-40 year age group. Methicillin resistance was found in 26 (36.11%) isolates. Cotrimoxazole prophylaxis was found to be a risk factor for MRSA colonization (P < 0.0001). Decreased CD4 counts was found to be a significant risk factor for MRSA colonization (P < 0.0001).


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