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ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 3  |  Page : 139-142

High serum peroxynitrite level is an early effect of chronic cigarette smoking


1 Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq
2 Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Marwan S. M. Al-Nimer
Professor of Pharmacology, Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.106083

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Background: Nicotine dependence is a chronic and relapsing disease. Oxidant components of cigarette smoke reduce nitric oxide (NO) production and/or inhibit its function. Objectives: The aim of this study was to assess serum NO, peroxynitrite ONOO and C-reactive protein in smoker individuals using the Fagerström test for nicotine dependence. Materials and Methods: A total number of 50 male smoker subjects and 20 non-smoker subjects serving as controls were recruited in this study. The Fagerström test of nicotine dependence was used to assess the level of nicotine dependence. Venous blood was obtained from each subject and serum was separated for the following tests: C-reactive protein, NO and ONOO. Results: The mean values of C-reactive proteins in the smokers were less than 6 mg/L and there was no significant difference in the C-reactive protein level between levels of nicotine dependence according to the Fagerström test scoring. A non-significant low serum NO level was observed in smokers, which did not correlate with C-reactive protein. A significant high serum ONOO level was observed in smokers compared with non-smoker subjects, which did not correlate with C-reactive protein. Conclusions: The study concludes that serum ONOO level may serve as an initial marker to point the impact of smoking on human beings. Its elevation preceded the decline in serum NO level and the evidence of inflammation.


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