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ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 92-98

Frequency of platelet aggregation defects in children suffering fromg β-thalassemia


Department of Haematology and Transfusion Medicine, Children's Hospital and The Institute of Child Health, Lahore, Pakistan

Correspondence Address:
Hammad Tufail Chaudhary
Assistant Professor of Pathology, Taif University, Taif, Saudi Arabia, 267 Gulshan Block, Allama Iqbal Town, Lahore
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.100962

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Background: β-thalassemia is a genetic disorder of hemoglobin synthesis, which is not uncommon in world's population. According to international studies, platelet aggregation is increased in splenectomized patients while it is decreased or normal in non-splenectomized adult patients and children. These findings are one of the indications of hypercoagulable state in β-thalassemia patients, which leads to thromboembolic disease. Aims: To determine the frequency of platelet aggregation defects in children (aged 6 months to 5 years) suffering from β-thalassemia. Settings and Design: This study was conducted in Department of Hematology and Transfusion Medicine of the Children's Hospital and Institute of Child Health, Lahore. It was a cross-sectional study. Subjects and Methods: We selected 100 β-thalassemia patients of age between 0 and 5 years. History taking, examination, and investigations like complete blood count (CBC), Hb-electrophoresis on High Performance Liquid Chromatography (HPLC), serum iron, and platelet aggregation were performed on these patients. Results: During the study period, 100 children fulfilling the inclusion criteria were selected, and platelet aggregation with ADP, collagen, and ristocetin, was performed. It was found out that 66, 62, and 69% of the children showed decreased aggregation with ADP, collagen, and ristocetin, respectively, while 34, 38, and 31% children were found to have normal aggregation with ADP, collagen, and ristocetin, respectively. Conclusions: It was found that majority of the children showed decreased aggregation with ADP, collagen and ristocetin.


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