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ORIGINAL ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 3  |  Page : 125-129

Assessment of serum interleukins-17 and 1β levels in hypertensive patients treated with angiotensin converting enzyme and/or angiotensin II receptor blockers


1 Department of Medicine, College of Medicine, Diyala University, Diyala, Iraq
2 Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Marwan S. M. Al-Nimer
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.195814

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Background: Low-grade inflammation plays a role in pathogenesis of hypertension. Some of antihypertensive agents have anti-inflammatory effects. Aims: This study aimed to compare the serum levels of interleukin-17 (IL-17) and IL-1β in hypertensive patients treated with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers with untreated hypertensive patients. Settings and Design: This observational study was carried in Departments of Medicine, College of Medicine, Diyala University in Iraq from June 2014 to December 2014. Materials and Methods: A total of 78 hypertensive patients treated with ACEIs and/or ARBs, and another 28 newly diagnosed hypertensive patients (without treatment at the time of admission into the study) were included in the study. Anthropometric measurements and the laboratory measurements included fasting serum lipid profile, and serum IL-1β and IL-17 levels as proinflammatory markers. Statistical Analysis: All calculations and analysis were made using Excel 2003 and SPSS program (version 17) for Windows. Results: There are nonsignificant differences in the anthropometric and lipid profile measurements between treated and untreated hypertensive patients. The blood pressure of patients treated with ARBs and/or ACEIs is significantly lower than the corresponding level of untreated patients but still higher than the cut-off level of 140/90 mmHg. Nonsignificant low serum IL-17 levels observed in treated hypertensive patients compared with untreated hypertensive patients. Significant inverse correlation between serum IL-17 with systolic (r = −0.420, P < 0.02) and diastolic (r = 0.491, P < 0.01) blood pressure observed in patients treated with ACEIs. Conclusions: We conclude that hypertensive patients treated with ACEIs and/or ARBs drugs showed inconsistent serum levels of IL-1β and IL-17 and a paradox is observed in the relation between these cytokines levels and blood pressure measurements.


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