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Year : 2015  |  Volume : 4  |  Issue : 3  |  Page : 156-162

Evaluation of antioxidant and hepatoprotective potential of Cinnamomum tamala leaves in rats

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

Correspondence Address:
Absar Ahmed Qureshi
Department of Pharmacology, College of Pharmacy, King Khalid University, Post Box: 1882, Abha 61441
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0521.171434

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Context: Health is one of the commonly mentioned motivations behind food choices, and functional foods offer promising health benefits. Aims: In this study, the folklore claim of Cinnamomum tamala leaves as hepatoprotective functional food is evaluated. Settings and Design: Prophylactic and curative hepatoprotective properties of selected functional food was carried out against commonly used analgesic antipyretic paracetamol (PCM). Subjects and Methods: Prophylactic and curative hepatoprotective property of suspension of C. tamala leaves (SCT) was studied against PCM-induced hepatic damage in albino rats. Pre- and post-treatment with SCT, before and after PCM treatment, reduced the biochemical markers of hepatic damage like serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, serum alkaline phosphatase, serum cholesterol, total and direct bilirubin, and tissue glutathione (GSH). Histopathological studies also revealed that pre- and post-treatment with SCT, before and after PCM treatment protected the liver from PCM-induced liver damage. In addition, an antioxidant study was carried out by in vitro lipid peroxidation. Statistical Analysis Used: Statistical analysis was performed with one-way analysis of variance (one-way) followed by Tukey test. Results: In this study, it has been found that prophylactic study showed better hepatoprotection than the curative study. Conclusions: In the prophylactic study, lipid peroxidation and protection of GSH may be the reason behind better hepatoprotection and C. tamala possess hepatoprotective activity possibly because of its antioxidant potential.

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