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ORIGINAL ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 81-86

The effect of Solenostemma argel on anemia related parameters in Albino Rats and Rabbits


1 Department of Biochemistry, University of National Ribat, Sudan
2 Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Sudan
3 Department of Zoology, Faculty of Science, University of Khartoum, Sudan

Correspondence Address:
H M Osman
Department of Biochemistry, Faculty of Pharmacy, University of the National Ribat. Khartoum
Sudan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.117911

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Background: The plant has been used for treatment of number of diseases in folklore medicine but not used for anemia. The present study is aimed to investigate its effect on anemia and related blood indices and body weights (BWs). Materials and Methods: Two sets of Albino rats each of four groups of six animals were used in this study. In each set one group for the control and the three groups for experimental doses. Two groups of rabbits each of five animals were also used for control and experiment. In one set of Albino rats, leaves of Solenostemma argel extracted in ethanol were used to test for its effect alone although in the second set, Albino rats were used to test for anemia. However, the rabbits were tested for the effect of S. argel on blood indices and BW. Blood parameters were measured by Sysmex, electrolytes by spectrophotometer, and flame photometer and BW by Mettler balance. Measurements were conducted after 30 days. Results: The present study revealed significant increases (P < 0.05) in mean cell hemoglobin concentration (MCHC) and packed cell volume (PCV) in rats provided with 600 mg/kg and PCV in the group provided with 300 mg/kg, whereas no significant changes in the group provided with 150 mg/kg. For rabbits significant increase (P < 0.05) was restricted in hemoglobin (Hb) and mean cell volume (MCV). However, no significant changes (P > 0.05) occurred in BWs of experimental animals. In the meantime, significant decreases (P < 0.01) in red blood cell counts, Hb, MCHC, PCV and Fe as well as increase in MCV occurred in those treated with Aluminum chloride (AlCl 3 ) alone (Al) group or Aluminum chloride co-administered with 600 mg/ kg of S. argel extract (AlS) group. The results also showed significant increase (P < 0.01) in PCV and MCHC and significant decrease in MCV in group treated with AlCl 3 co-administered with plant when compared to those provided with AlCl 3 alone. Moreover, administration of plant extracts alone (S) group lead to significant increase (P < 0.05) in MCHC, PCV, K, P, and Ca when compared to the control group (CG). Conclusion: The present study concludes that S. argel is of high nutritional values and of significance in mitigating anemia.


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