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REVIEW ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 61-68

Growth hormone and its receptor: A molecular insight


Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, Kingdom of Saudi Arabia

Correspondence Address:
Yahia A Kaabi
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, Dammam-Al-Khobar Cornish Road, P.O. Box 76447, Al-Khobar 31952
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0521.100942

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Growth hormone (GH) is a peptide hormone necessary for normal postnatal growth as well as human metabolism. It works via its widely expressed receptor (GHR), which is a dimer of transmembrane glycoproteins, belonging to cytokines type I receptor family. Signaling via GHR is initiated by conformational changes triggered upon GH association. GHR is recognized as an important therapeutic target for treatment of many pathologic conditions, including growth disorders and cancer by designing highly specific and efficient GHR agonists or antagonists. However, engineering of such molecules requires deep understanding of the structure and function of both GH and GHR protein molecules. This work reviews the current status of knowledge covering the molecular structure of both GH and GHR and their molecular interactions, in addition to different GH agonists or antagonists developed to regulate GH action.


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