Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
    Users Online: 328
Home Print this page Email this page Small font size Default font size Increase font size
EXPERIMENTAL STUDIES
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 16-22

Blood group O protects against complicated Plasmodium falciparum malaria by the mechanism of inducing high levels of anti-malarial IgG antibodies


1 Department of Microbiology, College of Medicine and Medical Science, Taif University, Taif, Saudi Arabia; Faculty of Science and Technology, Al Neelain University, Khartoum, Sudan
2 Department of Haematology, Faculty of Medical Laboratory Science, University of Medical Science and Technology, Khartoum, Sudan
3 Department of ENT, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
4 Department of Biochemistry, Faculty of Medicine, Malaria Research Centre (MalRC), University of Khartoum, Khartoum, Sudan; Department of Clinical Immunology, Faculty of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Amre Nasr
Department of Microbiology, College of Medicine and Medical Science, Taif University, P.O. Box: 888, Taif, Saudi Arabia

Login to access the Email id

Source of Support: Ministry of Higher Education and Research, Sudan (MHER.SD. 2009.4771)., Conflict of Interest: None


DOI: 10.4103/2278-0521.94979

Rights and Permissions

In a prospective clinical study in North Kordofan (Western Sudan), the possible association between blood groups and anti-malarial antibody responses with clinical outcome of Plasmodium falciparum malaria among Sudanese patients was investigated. A total of 184 individuals were consecutively enrolled from an outpatient clinic. Sixty six (35.9%) patients were classified as complicated malaria (CM), 53 (28.8%) with uncomplicated malaria (UM) and 65 (35.3%) were malaria free controls (MFC). Phenotypes of ABO blood groups were typed using commercial anti-sera. The antibody responses to MSP2 malaria antigens were assessed by an enzyme-linked immunosorbent assay (ELISA). The frequency of O blood group was significantly lower in those with CM when compared with MFC and UM patients (P value < 0.001 and 0.002 respectively). The levels of IgG1, IgG2 and IgG3 antibodies were statistically significantly higher in UM and MFC compared with CM patients. Statistical analysis indicated that higher levels of total IgG, IgG1, IgG2, and IgG3 specific to the MSP2 (both antigen forms, 3D7 and FC27) were associated with a reduced risk of complicated CM in O blood type carriers than in non-O blood type carriers, P value <0.001. Taken together, the current study indicates that blood group O is associated with a reduction in the risk of developing complicated malaria in western Sudan. Our results also revealed that the natural acquisition of immunity against clinical malaria appeared to be more associated with IgG1 and IgG3 antibodies, signifying their roles in parasite-neutralizing immune mechanisms.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5069    
    Printed220    
    Emailed1    
    PDF Downloaded587    
    Comments [Add]    
    Cited by others 2    

Recommend this journal